| Acetylcholine Receptor Binding Antibody | 206X |
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| CPT Code(s): 83519 | Clinical Significance: Myasthenia gravis (MG) is a neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. This assay aids in the differential diagnosis of MG-like muscle weakness, in differentiating between generalized MG and ocular MG, and in monitoring therapeutic response. If binding antibodies are negative, assays for blocking and modulating antibodies should be considered. |
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| Specimen Container: No additive (red-top) |
| Preferred Specimen: 1 mL serum (0.2 mL minimum) |
| Instructions: Serum is the only acceptable sample. |
| Transport Temperaturer: Room temperature |
| Methodology: Radioimmunoassay |
| Reference Range: Negative: < or = 0.30 nmol/L Equivocal: 0.31-0.49 nmol/L Positive: > or = 0.50 nmol/L |
